Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | ASAH1 | Q13510 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | STAT6 | P42226 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.40 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29145084 | 0.86 | ASAH1 (0.47) | SMN1; SMN2ASAH1KMT2ARAB9ANPC1 | |
| SCHEMBL29145099 | 0.82 | ASAH1 (0.53) | SMN1; SMN2ASAH1KMT2ARAB9ANPC1 | |
| SCHEMBL29145104 | 0.80 | ALDH1A1 (0.55) | SMN1; SMN2ASAH1KMT2ARAB9ANPC1 | |
| SCHEMBL20522520 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2ASAH1KMT2ARAB9ANPC1 | |
| SCHEMBL722366 | 0.80 | ASAH1 (0.57) | SMN1; SMN2ASAH1KMT2ARAB9ANPC1 | |
| SCHEMBL29145133 | 0.78 | ASAH1 (0.60) | SMN1; SMN2ASAH1KMT2ARAB9ANPC1 | |
| SCHEMBL29145145 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2ASAH1KMT2ARAB9ANPC1 | |
| SCHEMBL8744445 | 0.77 | ASAH1 (0.62) | SMN1; SMN2ASAH1KMT2ARAB9ANPC1 | |
| SCHEMBL29145161 | 0.77 | ASAH1 (0.62) | SMN1; SMN2ASAH1KMT2ARAB9ANPC1 | |
| SCHEMBL7163540 | 0.76 | ASAH1 (0.58) | SMN1; SMN2ASAH1KMT2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112789040-A | Transglutaminase 2(TG2) inhibitors | 思达利医药公司 | 2021-05-11 | — | — | CN | disclosed |