SCHEMBL28599644

SCHEMBL28599644

COc1cc(C(C)=O)ccc1C1CCCCC1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.55
MEN1 O00255 3/20 0.55
L3MBTL1 Q9Y468 1/20 0.46
PTGDR2 Q9Y5Y4 2/20 0.45
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
ALDH1A1 P00352 3/20 0.45
LMNA P02545 2/20 0.45
PKM P14618 1/20 0.45
ALOX15 P16050 1/20 0.45
PTGDR Q13258 1/20 0.44
CHRNA1 P02708 1/20 0.43
CHRNG P07510 1/20 0.43
CHRNB1 P11230 1/20 0.43
CHRNB2 P17787 1/20 0.43
CHRNB4 P30926 1/20 0.43
CHRNA3 P32297 1/20 0.43
CHRNA4 P43681 1/20 0.43
CHRND Q07001 1/20 0.43
PDE4B Q07343 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28604260 0.87 KMT2A (0.45) KMT2AMEN1PTGDR2NPC1RAB9A
SCHEMBL11445489 0.85 HTR2C (0.55) KMT2AMEN1ALDH1A1LMNACHRNA1
SCHEMBL28601814 0.83 PTGDR2 (0.47) KMT2AMEN1PTGDR2NPC1RAB9A
SCHEMBL28918438 0.83 GSK3B (0.45) KMT2AMEN1PTGDR2NPC1RAB9A
SCHEMBL3062913 0.80 KMT2A (0.48) KMT2AMEN1L3MBTL1NPC1RAB9A
SCHEMBL11233428 0.80 HSD17B2 (0.43) KMT2AMEN1PTGDR2NPC1RAB9A
SCHEMBL24209020 0.80 ALDH1A1 (0.47) KMT2AMEN1PTGDR2NPC1RAB9A
SCHEMBL28601823 0.80 ALDH1A1 (0.47) KMT2AMEN1PTGDR2NPC1RAB9A
SCHEMBL10186122 0.80 CA12 (0.61) KMT2AMEN1RAB9ALMNAPKM
SCHEMBL28610604 0.80 ALDH1A1 (0.47) KMT2AMEN1NPC1RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109020790-B Preparation method of 4-naphthenic acetophenone derivative 苏州大学 2021-07-27 CN disclosed