Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | TNKS | O95271 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29209082 | 0.83 | BRD4 (0.42) | MEN1KMT2ABRD4HTR2AHTR2C | |
| SCHEMBL13139310 | 0.83 | HTR2A (0.44) | MEN1KMT2AGRM5BRD4GAA | |
| SCHEMBL28597676 | 0.80 | MEN1 (0.55) | MEN1KMT2AGRM5BRD4GAA | |
| SCHEMBL8749812 | 0.73 | TAS1R3 (0.32) | SRD5A1 | |
| SCHEMBL25256410 | 0.73 | MEN1 (0.41) | MEN1KMT2AGRM5BRD4GAA | |
| SCHEMBL24771273 | 0.73 | SRD5A1 (0.36) | BRD4NPSR1SRD5A1 | |
| SCHEMBL30723049 | 0.73 | SRD5A1 (0.36) | BRD4NPSR1SRD5A1 | |
| SCHEMBL12715961 | 0.72 | HTR2A (0.44) | MEN1KMT2AGRM5HTR2AHTR2C | |
| SCHEMBL4751133 | 0.71 | TAS1R3 (0.34) | BRD4HTR2AHTR2CHTR2BMAPT | |
| SCHEMBL172065 | 0.71 | GRM5 (0.56) | MEN1KMT2AGRM5BRD4SRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113166139-A | Pyrrolo [2,3-b ] pyridines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-07-23 | — | — | CN | disclosed |