SCHEMBL28600591

SCHEMBL28600591

COC(=O)c1cc(OC[C@@H]2CCCN2C(=O)OC(C)(C)C)no1

nearest known ligand 0.43

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
F2RL3 Q96RI0 4/20 0.42
ALOX5AP P20292 3/20 0.42
FEN1 P39748 1/20 0.42
GPR119 Q8TDV5 2/20 0.40
USP30 Q70CQ3 3/20 0.40
UCHL1 P09936 1/20 0.40
ALDH1A1 P00352 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28600592 1.00 F2RL3 (0.42) F2RL3ALOX5APFEN1GPR119USP30
SCHEMBL28917974 1.00 F2RL3 (0.42) F2RL3ALOX5APFEN1GPR119USP30
SCHEMBL28775143 0.90 ALOX5AP (0.43) F2RL3ALOX5APFEN1GPR119USP30
SCHEMBL28775140 0.90 ALOX5AP (0.43) F2RL3ALOX5APFEN1GPR119USP30
SCHEMBL28601191 0.85 USP30 (0.42) USP30UCHL1ALDH1A1
SCHEMBL28601189 0.85 USP30 (0.42) USP30UCHL1ALDH1A1
SCHEMBL29808436 0.84 ALOX5AP (0.45) F2RL3ALOX5APFEN1GPR119USP30
SCHEMBL7368481 0.82 FAAH (0.45) GPR119USP30
SCHEMBL28775157 0.79 ALOX5AP (0.42) F2RL3ALOX5APFEN1GPR119USP30
SCHEMBL28775155 0.79 ALOX5AP (0.42) F2RL3ALOX5APFEN1GPR119USP30

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220402935-A1 HETEROCYCLIC COMPOUND FIMECS, INC. (JP) 2022-12-22 US disclosed
EP-4006037-A1 HETEROCYCLIC COMPOUND Fimecs, Inc. (JP) 2022-06-01 EP disclosed
CN-107459510-B Isoxazole compound and application thereof 华东师范大学 2021-06-25 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220402935-A1 HETEROCYCLIC COMPOUND IRAK1, IRAK2, IRAK4 F2RL3 1891/4885ALOX5AP 4055/4885FEN1 3336/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.