Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Felbinac. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.88 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.88 |
| ▸ | GAA | P10253 | 1/20 | 0.88 |
| ▸ | TSHR | P16473 | 1/20 | 0.88 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.88 |
| ▸ | HTT | P42858 | 1/20 | 0.88 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.64 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.64 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.60 |
| ▸ | RORC | P51449 | 1/20 | 0.57 |
| ▸ | RXRA | P19793 | 4/20 | 0.56 |
| ▸ | RXRB | P28702 | 4/20 | 0.56 |
| ▸ | RXRG | P48443 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Felbinac SCHEMBL7107700 | 0.94 | LMNA (0.91) | LMNAABCC4GAATSHRPTGS1 | |
| Felbinac SCHEMBL26084 | 0.94 | LMNA (1.00) | LMNAABCC4GAATSHRPTGS1 | |
| Felbinac SCHEMBL28284677 | 0.91 | LMNA (0.95) | LMNAABCC4GAATSHRPTGS1 | |
| Felbinac SCHEMBL28286222 | 0.91 | LMNA (0.95) | LMNAABCC4GAATSHRPTGS1 | |
| Felbinac SCHEMBL28284672 | 0.91 | LMNA (0.95) | LMNAABCC4GAATSHRPTGS1 | |
| Felbinac SCHEMBL384892 | 0.91 | LMNA (0.95) | LMNAABCC4GAATSHRPTGS1 | |
| Felbinac SCHEMBL28286223 | 0.91 | LMNA (0.95) | LMNAABCC4GAATSHRPTGS1 | |
| Felbinac SCHEMBL8844919 | 0.91 | LMNA (0.95) | LMNAABCC4GAATSHRPTGS1 | |
| Felbinac SCHEMBL28284752 | 0.91 | LMNA (0.95) | LMNAABCC4GAATSHRPTGS1 | |
| Felbinac SCHEMBL28284674 | 0.91 | LMNA (0.95) | LMNAABCC4GAATSHRPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108653221-B | Pharmaceutical dosage forms and uses thereof | 南京三迭纪医药科技有限公司 | 2021-09-07 | — | — | CN | disclosed |
| CN-108721242-B | Pharmaceutical dosage forms and uses thereof | 南京三迭纪医药科技有限公司 | 2021-03-02 | — | — | CN | disclosed |