Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 17/20 | 0.87 |
| ▸ | NPC1 | O15118 | 16/20 | 0.87 |
| ▸ | NAMPT | P43490 | 1/20 | 0.81 |
| ▸ | PKM | P14618 | 3/20 | 0.79 |
| ▸ | HPGD | P15428 | 2/20 | 0.79 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.79 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.79 |
| ▸ | RELA | Q04206 | 1/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.79 |
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2857152 | 0.88 | NPC1 (0.91) | RAB9ANPC1NAMPTPKMHPGD | |
| SCHEMBL10367090 | 0.85 | HPGD (0.72) | RAB9ANPC1NAMPTPKMHPGD | |
| SCHEMBL31610081 | 0.84 | RAB9A (0.71) | RAB9ANPC1NAMPTPKMHPGD | |
| SCHEMBL28704189 | 0.84 | HPGD (0.71) | RAB9ANPC1NAMPTPKMHPGD | |
| SCHEMBL2544046 | 0.83 | MAPK1 (1.00) | RAB9ANPC1NAMPTPKMHPGD | |
| SCHEMBL14132462 | 0.82 | NPC1 (1.00) | RAB9ANPC1NAMPTPKMHPGD | |
| SCHEMBL2854522 | 0.81 | MAPK1 (0.64) | RAB9ANPC1NAMPTPKMHPGD | |
| SCHEMBL2605692 | 0.81 | HPGD (0.76) | RAB9ANPC1NAMPTPKMHPGD | |
| SCHEMBL27405 | 0.81 | MAPK1 (0.78) | RAB9ANPC1NAMPTPKMHPGD | |
| SCHEMBL16615777 | 0.80 | NPC1 (0.66) | RAB9ANPC1NAMPTPKMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |