Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 16/20 | 0.91 |
| ▸ | RAB9A | P51151 | 16/20 | 0.91 |
| ▸ | PKM | P14618 | 3/20 | 0.91 |
| ▸ | NAMPT | P43490 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.65 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.65 |
| ▸ | RELA | Q04206 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MET | P08581 | 1/20 | 0.59 |
| ▸ | AXL | P30530 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2860286 | 0.88 | RAB9A (0.87) | NPC1RAB9APKMNAMPTMAPT | |
| SCHEMBL2857166 | 0.82 | HPGD (0.80) | NPC1RAB9APKMMAPTNFKB1 | |
| SCHEMBL2855932 | 0.82 | NPC1 (0.69) | NPC1RAB9APKMMAPTNFKB1 | |
| SCHEMBL2850131 | 0.81 | RAB9A (0.61) | NPC1RAB9APKMMAPTNFKB1 | |
| SCHEMBL2851942 | 0.81 | NPC1 (0.64) | NPC1RAB9APKMMAPTNFKB1 | |
| SCHEMBL26732894 | 0.78 | KDM4E (0.71) | NPC1RAB9APKMMAPTSMN1; SMN2 | |
| SCHEMBL28676362 | 0.78 | RAB9A (0.57) | NPC1RAB9APKMMAPTALDH1A1 | |
| SCHEMBL2860254 | 0.77 | RAB9A (0.60) | NPC1RAB9APKMMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6313314 | 0.77 | NPC1 (0.60) | NPC1RAB9APKMMAPTNFKB1 | |
| SCHEMBL2856505 | 0.77 | TP53 (0.59) | NPC1RAB9APKMMAPTNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |