Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28600582 | 0.86 | ALDH1A1 (0.41) | GPR119BRD4L3MBTL1MAPTALDH1A1 | |
| SCHEMBL1948855 | 0.76 | BCHE (0.44) | GPR119L3MBTL1ALDH1A1KDM4EMEN1 | |
| SCHEMBL28600580 | 0.75 | ALDH1A1 (0.41) | GPR119BRD4MAPTALDH1A1LMNA | |
| SCHEMBL2879064 | 0.74 | MCL1 (0.42) | GPR119BRD4L3MBTL1MAPTALDH1A1 | |
| SCHEMBL31370509 | 0.74 | L3MBTL1 (0.49) | GPR119BRD4L3MBTL1MAPTALDH1A1 | |
| SCHEMBL17690275 | 0.70 | NR1H2 (0.45) | GPR119BRD4MAPTALDH1A1HPGD | |
| SCHEMBL3892320 | 0.68 | ESR2 (0.56) | GPR119L3MBTL1MAPTALDH1A1HPGD | |
| SCHEMBL5952979 | 0.68 | MAPT (0.39) | GPR119BRD4L3MBTL1MAPTALDH1A1 | |
| SCHEMBL25736835 | 0.68 | MAPT (0.46) | GPR119BRD4L3MBTL1MAPTALDH1A1 | |
| SCHEMBL14051459 | 0.68 | L3MBTL1 (0.46) | GPR119L3MBTL1HTR6AKR1C3NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113105459-A | Triazolopyrimidine derivative and preparation method and application thereof | 五邑大学 | 2021-07-13 | — | — | CN | claimed |
| CN-113105459-B | Triazolopyrimidine derivative and preparation method and application thereof | 五邑大学 | 2022-05-03 | — | — | CN | disclosed |
| CN-113105459-A | Triazolopyrimidine derivative and preparation method and application thereof | 五邑大学 | 2021-07-13 | — | — | CN | disclosed |