Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL700726 | 0.84 | HPGD (0.41) | PTPN2PTPN1PTPN6GPR119NPC1 | |
| SCHEMBL716216 | 0.84 | HPGD (0.41) | PTPN2PTPN1PTPN6GPR119NPC1 | |
| SCHEMBL6348401 | 0.82 | GPR119 (0.42) | PTPN2PTPN1PTPN6GPR119NPC1 | |
| SCHEMBL20202781 | 0.80 | DPP4 (0.44) | PTPN2PTPN1PTPN6GPR119NPC1 | |
| SCHEMBL21748879 | 0.79 | NR1H2 (0.39) | GPR119HPGDALDH1A1JAK2JAK1 | |
| SCHEMBL31164732 | 0.78 | USP30 (0.38) | PTPN2PTPN1PTPN6GPR119NPC1 | |
| SCHEMBL29560344 | 0.77 | NR1H2 (0.41) | ALDH1A1USP2SMN1; SMN2MAPT | |
| SCHEMBL16728425 | 0.76 | NR1H2 (0.42) | GPR119HPGDALDH1A1JAK2JAK1 | |
| SCHEMBL17474491 | 0.76 | RORC (0.47) | GPR119 | |
| SCHEMBL17474521 | 0.76 | RORC (0.47) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053742-B | Novel tricyclic compounds | ABBVIE 公司 | 2021-06-15 | — | — | CN | disclosed |