SCHEMBL28604608

SCHEMBL28604608

COc1ccc(C2(Cn3cncn3)OCC(C)CO2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 2/20 0.53
NPSR1 Q6W5P4 1/20 0.53
ALDH1A1 P00352 1/20 0.46
MAPT P10636 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
CYP3A4 P08684 11/20 0.43
THRB P10828 1/20 0.43
TSHR P16473 2/20 0.38
NR1I2 O75469 1/20 0.38
LMNA P02545 1/20 0.38
FYN P06241 1/20 0.38
PGR P06401 1/20 0.38
CHRM2 P08172 1/20 0.38
CHRM4 P08173 1/20 0.38
CHRM5 P08912 1/20 0.38
ADRA2A P08913 1/20 0.38
CHRM1 P11229 1/20 0.38
ADRA2B P18089 1/20 0.38
ADRA2C P18825 1/20 0.38
CHRM3 P20309 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11547531 0.88 HSP90AA1 (0.56) HSP90AA1NPSR1ALDH1A1MAPTSMN1; SMN2
SCHEMBL28602340 0.88 HSP90AA1 (0.56) HSP90AA1NPSR1ALDH1A1MAPTSMN1; SMN2
SCHEMBL28612952 0.88 HSP90AA1 (0.56) HSP90AA1NPSR1ALDH1A1MAPTSMN1; SMN2
SCHEMBL11541496 0.88 ALDH1A1 (0.50) HSP90AA1NPSR1ALDH1A1MAPTSMN1; SMN2
SCHEMBL28614551 0.85 CYP3A4 (0.58) HSP90AA1NPSR1ALDH1A1SMN1; SMN2CYP3A4
SCHEMBL11542005 0.85 ALDH1A1 (0.48) HSP90AA1NPSR1ALDH1A1MAPTSMN1; SMN2
SCHEMBL28919655 0.85 HSP90AA1 (0.55) HSP90AA1NPSR1CYP3A4THRBTSHR
SCHEMBL28613068 0.85 HSP90AA1 (0.55) HSP90AA1NPSR1CYP3A4THRBTSHR
SCHEMBL28920269 0.85 HSP90AA1 (0.54) HSP90AA1NPSR1SMN1; SMN2CYP3A4THRB
SCHEMBL28608939 0.84 ALDH1A1 (0.47) HSP90AA1NPSR1ALDH1A1MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113234066-A Propiconazole-like compound and preparation method and application thereof 浙江工业大学 2021-08-10 CN disclosed