SCHEMBL28604615

SCHEMBL28604615

CC1(C)COC(Cn2cncn2)(c2ccc(C(F)(F)F)cc2)OC1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 2/20 0.45
NPSR1 Q6W5P4 1/20 0.45
CYP3A4 P08684 8/20 0.37
THRB P10828 1/20 0.37
CYP2C9 P11712 5/20 0.37
CYP1A2 P05177 4/20 0.37
CYP2C19 P33261 4/20 0.37
CYP2D6 P10635 3/20 0.37
KDM4E B2RXH2 1/20 0.33
ALOX15 P16050 1/20 0.33
GAA P10253 1/20 0.33
HSD17B10 Q99714 1/20 0.33
KIF11 P52732 1/20 0.32
KMT2A Q03164 1/20 0.32
SLC6A2 P23975 1/20 0.31
SLC6A4 P31645 1/20 0.31
SLC6A3 Q01959 1/20 0.31
LRRK2 Q5S007 1/20 0.31
CYP11B2 P19099 1/20 0.31
TACR1 P25103 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28606557 0.88 HSP90AA1 (0.46) HSP90AA1NPSR1CYP3A4THRBCYP2C9
SCHEMBL28602343 0.86 CYP3A4 (0.47) HSP90AA1NPSR1CYP3A4THRBCYP2C9
SCHEMBL28603082 0.85 HSP90AA1 (0.52) HSP90AA1NPSR1CYP3A4THRBCYP2C9
SCHEMBL28604617 0.84 HSP90AA1 (0.47) HSP90AA1NPSR1CYP3A4THRBCYP2C9
SCHEMBL28608979 0.84 CYP3A4 (0.51) HSP90AA1NPSR1CYP3A4THRBCYP2C9
SCHEMBL28612956 0.84 GAA (0.47) HSP90AA1NPSR1CYP3A4THRBCYP2C9
SCHEMBL9567500 0.82 HSP90AA1 (0.40) HSP90AA1NPSR1CYP3A4THRBCYP2C9
SCHEMBL28608939 0.82 ALDH1A1 (0.47) HSP90AA1NPSR1CYP3A4THRBCYP2C9
SCHEMBL28604621 0.81 HSP90AA1 (0.55) HSP90AA1NPSR1CYP3A4THRBCYP2C9
SCHEMBL28611578 0.81 HSP90AA1 (0.55) HSP90AA1NPSR1CYP3A4THRBCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113234066-A Propiconazole-like compound and preparation method and application thereof 浙江工业大学 2021-08-10 CN disclosed