Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28606708 | 0.87 | RPS6KA5 (0.40) | ALDH1A1MAPTKDM4ENPSR1MKNK1 | |
| SCHEMBL28608545 | 0.84 | HPGD (0.36) | ALDH1A1MAPTKDM4ENPSR1MKNK2 | |
| SCHEMBL19100394 | 0.81 | PIN1 (0.40) | PIN1IMPDH2CSNK1A1CLK4 | |
| SCHEMBL28600554 | 0.78 | RPS6KA5 (0.39) | KDM4E | |
| SCHEMBL28607844 | 0.77 | RPS6KA5 (0.40) | ALDH1A1MAPTKDM4ENPSR1MKNK1 | |
| SCHEMBL28619153 | 0.75 | MAPT (0.42) | PIN1ALDH1A1MAPTKDM4ENPSR1 | |
| SCHEMBL28612361 | 0.74 | CSNK1A1 (0.46) | PIN1ALDH1A1MAPTKDM4ENPSR1 | |
| SCHEMBL28612373 | 0.74 | PIN1 (0.41) | PIN1ALDH1A1MAPTKDM4ENPSR1 | |
| SCHEMBL19100385 | 0.69 | RPS6KA5 (0.35) | MKNK1 | |
| SCHEMBL19100706 | 0.68 | CYP11B2 (0.32) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109328059-B | Selective inhibitors of clinically important mutants of EGFR tyrosine kinase | CS制药技术有限公司 | 2021-08-17 | — | — | CN | disclosed |
| CN-109328059-A | Selective inhibitors of clinically important mutants of EGFR tyrosine kinase | CS制药技术有限公司 | 2019-02-12 | — | — | CN | disclosed |