Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 17/20 | 0.57 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.46 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5533351 | 1.00 | GABRA5 (0.57) | GABRA5GABRA1ITGA5 | |
| SCHEMBL285557 | 0.95 | GABRA5 (0.59) | GABRA5ITGA5 | |
| SCHEMBL18092038 | 0.86 | GABRA5 (0.54) | GABRA5GABRA1 | |
| SCHEMBL18092005 | 0.86 | GABRA5 (0.54) | GABRA5GABRA1 | |
| SCHEMBL285976 | 0.83 | GABRA5 (0.59) | GABRA5GABRA1ITGA5 | |
| SCHEMBL18092045 | 0.82 | GABRA5 (0.55) | GABRA5ITGA5 | |
| SCHEMBL286137 | 0.81 | L3MBTL1 (0.46) | GABRA5 | |
| SCHEMBL285524 | 0.81 | CHRM4 (0.41) | GABRA5GABRA1ITGA5 | |
| SCHEMBL285660 | 0.80 | SMN1; SMN2 (0.48) | GABRA5 | |
| SCHEMBL285890 | 0.80 | GABRA5 (0.52) | GABRA5GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427459-A1 | ISOXAZOLE-THIAZOLE DERIVATIVES AS GABA A RECEPTOR INVERSE AGONISTS FOR USE IN THE TREATMENT OF COGNITIVE DISORDERS | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |