Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24234121 | 0.78 | TSHR (0.47) | CYP2C9TSHRKDM4EALDH1A1TDP1 | |
| SCHEMBL22116380 | 0.77 | CSNK2A1 (0.43) | CYP2C9TSHRALDH1A1TDP1KMT2A | |
| SCHEMBL22116370 | 0.76 | SMN1; SMN2 (0.37) | CYP2C9TSHRKDM4EALDH1A1TDP1 | |
| SCHEMBL20151866 | 0.75 | MGLL (0.48) | MGLLKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL22116320 | 0.73 | NPSR1 (0.34) | NPSR1CYP2C9TSHRALDH1A1KMT2A | |
| SCHEMBL22116354 | 0.73 | TSHR (0.45) | CYP2C9TSHRKDM4EALDH1A1TDP1 | |
| SCHEMBL24234027 | 0.72 | CFTR (0.32) | ATMP2RX3 | |
| SCHEMBL22116403 | 0.72 | PTGDR2 (0.42) | TSHRKMT2AMEN1LMNAHPGD | |
| SCHEMBL22116314 | 0.72 | KMT2A (0.33) | NPSR1CYP2C9TSHRKDM4EALDH1A1 | |
| SCHEMBL28605968 | 0.71 | ALDH1A1 (0.40) | NPSR1KDM4EALDH1A1TDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113226464-A | N- (pyridin-2-ylsulfonyl) cyclopropanecarboxamide derivatives and their use in the treatment of CFTR mediated diseases | 诺华股份有限公司 | 2021-08-06 | — | — | CN | disclosed |