Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27059331 | 0.85 | SMN1; SMN2 (0.59) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL30891597 | 0.76 | PREP (0.47) | SMN1; SMN2CYP2C19NPC1RAB9A | |
| SCHEMBL266047 | 0.75 | SMN1; SMN2 (0.67) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL1189968 | 0.75 | SMN1; SMN2 (0.67) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL6524693 | 0.75 | SMN1; SMN2 (0.67) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL27278368 | 0.74 | AXL (0.42) | SMN1; SMN2CYP2C19NPC1RAB9ACYP2C9 | |
| Hydrochloric Acid SCHEMBL2514584 | 0.74 | SMN1; SMN2 (0.65) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL504825 | 0.74 | SMN1; SMN2 (0.68) | SMN1; SMN2CYP2C19NPC1RAB9AJAK1 | |
| Hydrochloric Acid SCHEMBL6175666 | 0.74 | SMN1; SMN2 (0.65) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| Hydrochloric Acid SCHEMBL716733 | 0.74 | SMN1; SMN2 (0.65) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118290403-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-113993861-B | Phenyl ethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-113993861-A | Phenylethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2022-01-28 | — | — | CN | disclosed |
| CN-113227074-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods | 凌科药业(杭州)有限公司 | 2021-08-06 | — | — | CN | disclosed |