Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 17/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17980578 | 0.86 | LRRK2 (0.36) | LRRK2RETDCLK1 | |
| SCHEMBL7449816 | 0.78 | LRRK2 (0.53) | LRRK2 | |
| SCHEMBL28593022 | 0.78 | LRRK2 (0.54) | LRRK2 | |
| SCHEMBL28591970 | 0.77 | HTR2C (0.44) | LRRK2 | |
| SCHEMBL28081293 | 0.75 | LRRK2 (0.52) | LRRK2 | |
| SCHEMBL7459019 | 0.75 | LRRK2 (0.50) | LRRK2 | |
| SCHEMBL14995754 | 0.73 | LRRK2 (0.67) | LRRK2 | |
| SCHEMBL11876693 | 0.71 | XDH (0.39) | — | |
| SCHEMBL17980576 | 0.71 | LRRK2 (0.50) | LRRK2 | |
| SCHEMBL3699681 | 0.70 | TTK (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113563342-A | LRRK2 inhibitors and methods of making and using the same | 达纳－法伯癌症研究所公司 | 2021-10-29 | — | — | CN | disclosed |
| CN-107801397-B | LRRK2 inhibitors and methods of making and using the same | 达纳－法伯癌症研究所公司 | 2021-07-30 | — | — | CN | disclosed |