Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 15/20 | 0.50 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7449816 | 0.89 | LRRK2 (0.53) | LRRK2 | |
| SCHEMBL28081293 | 0.85 | LRRK2 (0.52) | LRRK2ALK | |
| SCHEMBL14995754 | 0.85 | LRRK2 (0.67) | LRRK2 | |
| SCHEMBL7454699 | 0.80 | LRRK2 (0.51) | LRRK2 | |
| SCHEMBL25302280 | 0.76 | LRRK2 (0.50) | LRRK2ALK | |
| SCHEMBL28609552 | 0.75 | LRRK2 (0.40) | LRRK2 | |
| SCHEMBL28591970 | 0.75 | HTR2C (0.44) | LRRK2 | |
| SCHEMBL20537316 | 0.75 | ULK1 (0.50) | LRRK2ALK | |
| SCHEMBL14556210 | 0.75 | LRRK2 (0.51) | LRRK2ALK | |
| SCHEMBL7456753 | 0.74 | LRRK2 (0.77) | LRRK2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3075730-B1 | AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | GENENTECH INC (US) | 2018-10-24 | — | — | EP | disclosed |
| EP-3075730-A1 | AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2016-10-05 | — | — | EP | disclosed |
| CN-105837519-A | AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | 霍夫曼-拉罗奇有限公司 | 2016-08-10 | — | — | CN | disclosed |
| EP-2576541-B1 | AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | HOFFMANN LA ROCHE (CH) | 2016-04-06 | — | — | EP | disclosed |
| EP-2576541-A1 | AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011151360-A1 | AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-08 | — | — | WO | disclosed |