Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 18/20 | 0.71 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.64 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.64 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.64 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 1/20 | 0.64 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.64 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.64 |
| ▸ | MAOA | P21397 | 1/20 | 0.64 |
| ▸ | DRD4 | P21917 | 1/20 | 0.64 |
| ▸ | MAOB | P27338 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
| ▸ | HRH1 | P35367 | 1/20 | 0.64 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.64 |
| ▸ | DRD3 | P35462 | 1/20 | 0.64 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.64 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28919592 | 0.93 | OPRM1 (0.72) | OPRM1SIGMAR1SLC22A1NR1I2ABCB1 | |
| SCHEMBL11321588 | 0.87 | OPRM1 (0.69) | OPRM1SIGMAR1SLC22A1NR1I2ABCB1 | |
| SCHEMBL28611339 | 0.87 | OPRM1 (0.69) | OPRM1SIGMAR1SLC22A1NR1I2ABCB1 | |
| SCHEMBL28594947 | 0.85 | ACHE (0.58) | OPRM1SIGMAR1SLC22A1NR1I2ABCB1 | |
| SCHEMBL2056510 | 0.85 | OPRM1 (0.85) | OPRM1SIGMAR1SLC22A1NR1I2ABCB1 | |
| SCHEMBL13284174 | 0.85 | OPRM1 (0.85) | OPRM1SIGMAR1SLC22A1NR1I2ABCB1 | |
| SCHEMBL28597473 | 0.83 | OPRM1 (0.92) | OPRM1 | |
| SCHEMBL28602605 | 0.83 | OPRM1 (1.00) | OPRM1 | |
| SCHEMBL28602839 | 0.82 | OPRM1 (0.70) | OPRM1SIGMAR1 | |
| SCHEMBL11749530 | 0.82 | OPRM1 (0.64) | OPRM1SIGMAR1SLC22A1NR1I2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113214140-B | Piperidine amide derivative, pharmaceutical composition and application thereof | 江苏谛奇医药科技有限公司 | 2022-09-09 | — | — | CN | claimed |
| CN-113214140-A | Piperidine amide derivative, pharmaceutical composition and application thereof | 江苏谛奇医药科技有限公司 | 2021-08-06 | — | — | CN | claimed |
| CN-113214140-B | Piperidine amide derivative, pharmaceutical composition and application thereof | 江苏谛奇医药科技有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-113214139-B | Piperidine amide derivative, preparation method thereof, pharmaceutical composition thereof, single crystal culture method thereof and application thereof | 江苏谛奇医药科技有限公司 | 2022-03-04 | — | — | CN | disclosed |
| CN-113214140-A | Piperidine amide derivative, pharmaceutical composition and application thereof | 江苏谛奇医药科技有限公司 | 2021-08-06 | — | — | CN | disclosed |
| CN-113214139-A | Piperidine amide derivative, preparation method thereof, pharmaceutical composition thereof, single crystal culture method thereof and application thereof | 江苏谛奇医药科技有限公司 | 2021-08-06 | — | — | CN | disclosed |