Sugi Predict

Sugi Predict / Compounds / SCHEMBL2861035

SCHEMBL2861035

SCHEMBL2861035

CCOC(=O)c1ccc(-c2ccnc(Nc3ccc(I)cc3)n2)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 2/20 0.55
▸ RAB9A P51151 2/20 0.55
▸ KMT2A Q03164 2/20 0.55
▸ THRB P10828 1/20 0.55
▸ CAMK2D Q13557 5/20 0.54
▸ MAPK8 P45983 1/20 0.52
▸ MAPK10 P53779 1/20 0.52
▸ JAK2 O60674 2/20 0.51
▸ JAK3 P52333 2/20 0.51
▸ PDPK1 O15530 1/20 0.51
▸ MAPT P10636 1/20 0.49
▸ SLC2A1 P11166 1/20 0.49
▸ IKBKB O14920 2/20 0.48
▸ SYK P43405 1/20 0.48
▸ ALK Q9UM73 1/20 0.48
▸ KDR P35968 1/20 0.47
▸ NPC1 O15118 1/20 0.47
▸ ALDH1A1 P00352 1/20 0.47
▸ CASP3 P42574 1/20 0.47
▸ SMN1; SMN2 Q16637 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23897367 0.91 MEN1 (0.57) MEN1RAB9AKMT2ATHRBCAMK2D
SCHEMBL4071652 0.89 MAPK8 (0.67) MEN1RAB9AKMT2ATHRBCAMK2D
SCHEMBL3947629 0.84 ABL1 (0.62) MEN1RAB9AKMT2ATHRBMAPK8
SCHEMBL2866252 0.83 IKBKB (0.53) MEN1RAB9AKMT2ATHRBCAMK2D
SCHEMBL2856029 0.82 JAK2 (0.72) CAMK2DMAPK8MAPK10JAK2JAK3
SCHEMBL4354673 0.81 CDK2 (0.65) MAPK8JAK2IKBKBPIK3CAPIK3CB
SCHEMBL3946636 0.81 RAB9A (0.57) MEN1RAB9AKMT2ATHRBJAK2
SCHEMBL3947916 0.81 RAB9A (0.56) MEN1RAB9AKMT2ATHRBJAK2
SCHEMBL30715189 0.80 JAK2 (0.59) CAMK2DMAPK8MAPK10JAK2JAK3
SCHEMBL3949128 0.79 SYK (0.69) MEN1RAB9AKMT2ATHRBJAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220388967-A1 Phenyl Amino Pyrimidine Compounds and Uses Thereof SIERRA ONCOLOGY, INC. (US) 2022-12-08 — — US claimed
CN-104030990-B Phenyl amino pyrimidine compounds and application thereof YM生物科学澳大利亚私人有限公司 2017-01-04 — — CN claimed
EP-3023422-A1 PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF YM BioSciences Australia Pty Ltd (AU) 2016-05-25 — — EP claimed
US-20140011803-A1 PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF GLAXOSMITHKLINE LLC 2014-01-09 — — US claimed
CN-101861313-A Phenylaminopyrimidine compounds and their use CYTOPIA RES PTY LTD 2010-10-13 — — CN claimed
US-20100197671-A1 PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF GLAXOSMITHKLINE LLC 2010-08-05 — — US claimed
EP-2152701-A1 PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF Cytopia Research Pty Ltd (AU) 2010-02-17 — — EP claimed
WO-2008109943-A1 PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF CYTOPIA RESEARCH PTY LTD (AU) 2008-09-18 — — WO claimed
US-12570614-B2 Phenyl amino pyrimidine compounds and uses thereof GLAXOSMITH KLINE LLC (US) 2026-03-10 — — US disclosed
US-20220388967-A1 Phenyl Amino Pyrimidine Compounds and Uses Thereof SIERRA ONCOLOGY, INC. (US) 2022-12-08 — — US disclosed
US-20210309615-A1 PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF GLAXOSMITHKLINE LLC 2021-10-07 — — US disclosed
US-20210309615-A1 PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF GLAXOSMITHKLINE LLC 2021-10-07 — — US disclosed
EP-3023422-A1 PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF YM BioSciences Australia Pty Ltd (AU) 2016-05-25 — — EP disclosed
US-9238628-B2 Phenyl amino pyrimidine compounds and uses thereof YM Biosicences Australia PTY LTD (US) 2016-01-19 — — US disclosed
US-8486941-B2 Phenyl amino pyrimidine compounds and uses thereof YM BIOSCIENCES AUSTRALIA PTY LTD (AU) 2013-07-16 — — US disclosed
US-8486941-B2 Phenyl amino pyrimidine compounds and uses thereof YM BIOSCIENCES AUSTRALIA PTY LTD (AU) 2013-07-16 — — US disclosed
US-8486941-B2 Phenyl amino pyrimidine compounds and uses thereof YM BIOSCIENCES AUSTRALIA PTY LTD (AU) 2013-07-16 — — US disclosed
US-20100197671-A1 PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF GLAXOSMITHKLINE LLC 2010-08-05 — — US disclosed
US-20100197671-A1 PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF GLAXOSMITHKLINE LLC 2010-08-05 — — US disclosed
US-20100197671-A1 PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF GLAXOSMITHKLINE LLC 2010-08-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100197671-A1 PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF JAK2, JAK1, JAK3 MEN1 4037/4885RAB9A 3849/4885KMT2A 835/4885
US-12570614-B2 Phenyl amino pyrimidine compounds and uses thereof JAK1, JAK2, JAK3 MEN1 4629/4885RAB9A 3888/4885KMT2A 1370/4885
US-20140011803-A1 PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF JAK2, JAK1, JAK3 MEN1 4037/4885RAB9A 3849/4885KMT2A 835/4885
US-20210309615-A1 PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF JAK2, JAK1, JAK3 MEN1 4037/4885RAB9A 3849/4885KMT2A 835/4885
US-20220388967-A1 Phenyl Amino Pyrimidine Compounds and Uses Thereof JAK2, JAK1, JAK3 MEN1 4037/4885RAB9A 3849/4885KMT2A 835/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.