Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.37 |
| ▸ | PLK1 | P53350 | 3/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.33 |
| ▸ | INSR | P06213 | 2/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 6/20 | 0.30 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19633355 | 0.90 | FGFR1 (0.42) | FGFR1FGFR2FGFR4FGFR3PLK1 | |
| SCHEMBL19633409 | 0.89 | FGFR1 (0.42) | FGFR1FGFR2FGFR4FGFR3PLK1 | |
| SCHEMBL28610611 | 0.88 | FGFR1 (0.48) | FGFR1FGFR2FGFR4FGFR3PLK1 | |
| SCHEMBL28622672 | 0.86 | FGFR1 (0.51) | FGFR1FGFR2FGFR4FGFR3EGFR | |
| SCHEMBL28607392 | 0.84 | FGFR1 (0.52) | FGFR1FGFR2FGFR4FGFR3PLK1 | |
| SCHEMBL19633296 | 0.83 | FGFR1 (0.43) | FGFR1FGFR2FGFR4FGFR3PLK1 | |
| SCHEMBL30745814 | 0.82 | FGFR1 (0.40) | FGFR1FGFR2FGFR4FGFR3PLK1 | |
| SCHEMBL20836806 | 0.82 | FGFR1 (0.40) | FGFR1FGFR2FGFR4FGFR3PLK1 | |
| SCHEMBL30745796 | 0.80 | FGFR1 (0.33) | FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL20836818 | 0.80 | FGFR1 (0.33) | FGFR1FGFR2FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107400092-B | Pyrimidine derivative, preparation method thereof and application thereof in medicine | 浙江海正药业股份有限公司 | 2021-08-24 | — | — | CN | disclosed |