Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 11/20 | 0.48 |
| ▸ | CTSK | P43235 | 10/20 | 0.48 |
| ▸ | CTSL | P07711 | 2/20 | 0.46 |
| ▸ | CTSB | P07858 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 5/20 | 0.43 |
| ▸ | PPARG | P37231 | 4/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28613327 | 1.00 | CTSS (0.48) | CTSSCTSKCTSLCTSBPPARA | |
| SCHEMBL28961693 | 0.86 | CTSK (0.44) | CTSSCTSKCTSLCTSB | |
| SCHEMBL22109891 | 0.86 | CTSK (0.44) | CTSSCTSKCTSLCTSB | |
| SCHEMBL1429918 | 0.86 | CTSK (0.61) | CTSSCTSKCTSLCTSBPPARA | |
| SCHEMBL2399357 | 0.86 | CTSK (0.61) | CTSSCTSKCTSLCTSBPPARA | |
| SCHEMBL1429799 | 0.86 | CTSK (0.61) | CTSSCTSKCTSLCTSBPPARA | |
| SCHEMBL17533115 | 0.82 | CTSS (0.46) | CTSSCTSKCTSLCTSBPPARA | |
| SCHEMBL1952503 | 0.81 | CTSS (0.61) | CTSSCTSKCTSLCTSB | |
| SCHEMBL999757 | 0.81 | CTSS (0.61) | CTSSCTSKCTSLCTSB | |
| SCHEMBL17708331 | 0.81 | CTSS (0.61) | CTSSCTSKCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113195473-B | Tricyclic compound as STING agonist and preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-113195473-A | Tricyclic compound as STING agonist and preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2021-07-30 | — | — | CN | disclosed |