Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27701503 | 0.84 | RECQL (0.46) | MEN1KMT2A | |
| SCHEMBL3946630 | 0.83 | ADORA2A (0.45) | PLA2G10PLA2G2ABRD4MEN1KMT2A | |
| SCHEMBL30634304 | 0.81 | PLA2G10 (0.50) | PLA2G10PLA2G2ABRD4MEN1KMT2A | |
| SCHEMBL21753309 | 0.80 | PLA2G10 (0.42) | PLA2G10PLA2G2ABRD4MEN1KMT2A | |
| SCHEMBL9329423 | 0.80 | HCAR2 (0.45) | MEN1KMT2ABCL2BCL2L1 | |
| SCHEMBL17397579 | 0.76 | CYP2C9 (0.43) | KMT2APIM1 | |
| SCHEMBL28492022 | 0.75 | KDM4E (0.47) | PLA2G10PLA2G2ABCL2BCL2L1 | |
| SCHEMBL30006999 | 0.75 | KDM4E (0.47) | PLA2G10PLA2G2ABCL2BCL2L1 | |
| SCHEMBL28948571 | 0.75 | PIM1 (0.38) | MEN1KMT2APIM1 | |
| SCHEMBL27892338 | 0.73 | PIM1 (0.37) | KMT2APIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113272294-A | 2, 6-bis (((1H-benzo [ D ] imidazol-2-yl) thio) methyl) pyridine and N2, N6-dibenzylpyridine-2, 6-dicarboxamide derivatives and related compounds as phosphoinositide 3-kinase (PI3K) inhibitors for the treatment of cancer | 雅典学院生物医学研究基金会 | 2021-08-17 | — | — | CN | disclosed |