Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | HTR1F | P30939 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GALR2 | O43603 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28551485 | 0.85 | QDPR (0.55) | KMT2AMAPTNPSR1PKMPOLB | |
| SCHEMBL28537113 | 0.84 | MAPT (0.46) | KMT2AMAPTNPSR1PKMPOLB | |
| SCHEMBL28920609 | 0.80 | MAPT (0.50) | KMT2AMAPTNPSR1PKMPOLB | |
| SCHEMBL28543598 | 0.79 | NAMPT (0.52) | KMT2AMAPTNPSR1 | |
| SCHEMBL3030017 | 0.78 | HPGD (0.42) | KMT2AMAPTTP53HTTKDM4E | |
| SCHEMBL2282371 | 0.76 | MAPT (0.68) | KMT2AMAPTNPSR1PKMPOLB | |
| SCHEMBL28538188 | 0.76 | MAPT (0.49) | KMT2AMAPTNPSR1PKMPOLB | |
| SCHEMBL29119480 | 0.75 | TP53 (0.55) | KMT2AMAPTNPSR1TP53PKM | |
| SCHEMBL13041550 | 0.73 | KMT2A (0.49) | KMT2AMAPTNPSR1TP53PKM | |
| SCHEMBL2660796 | 0.72 | MAPT (0.48) | KMT2AMAPTNPSR1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107400092-B | Pyrimidine derivative, preparation method thereof and application thereof in medicine | 浙江海正药业股份有限公司 | 2021-08-24 | — | — | CN | disclosed |