Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 6/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | GALR3 | O60755 | 1/20 | 0.51 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.51 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.50 |
| ▸ | CDK2 | P24941 | 3/20 | 0.50 |
| ▸ | CDK4 | P11802 | 2/20 | 0.50 |
| ▸ | CCND1 | P24385 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29871021 | 1.00 | EPAS1 (0.54) | EPAS1EGFRGALR3NR2F2CCNE2 | |
| SCHEMBL16095196 | 0.78 | EPAS1 (0.51) | EPAS1MAPTTP53LMNARXFP1 | |
| SCHEMBL30002485 | 0.78 | EPAS1 (0.51) | EPAS1MAPTTP53LMNARXFP1 | |
| SCHEMBL28613599 | 0.77 | EPAS1 (0.50) | EPAS1EGFRLMNA | |
| SCHEMBL28624490 | 0.77 | EPAS1 (0.50) | EPAS1EGFRLMNA | |
| SCHEMBL7085874 | 0.74 | EPAS1 (0.46) | EPAS1MAPTTP53LMNARXFP1 | |
| SCHEMBL11443229 | 0.73 | EPAS1 (0.61) | EPAS1MAPTTP53LMNA | |
| SCHEMBL9361501 | 0.70 | EPAS1 (1.00) | EPAS1EGFRMEN1MAPTKMT2A | |
| SCHEMBL29791659 | 0.70 | EPAS1 (1.00) | EPAS1EGFRMEN1MAPTKMT2A | |
| SCHEMBL7221443 | 0.70 | EGFR (1.00) | EGFRGALR3NR2F2TNFRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113292510-B | Benzisothiazole compound for inhibiting hypoxia inducible factor 2 activity, preparation method and application thereof | 中国药科大学 | 2022-08-26 | — | — | CN | disclosed |
| CN-113292510-A | Benzisothiazole compound for inhibiting hypoxia inducible factor 2 activity, preparation method and application thereof | 中国药科大学 | 2021-08-24 | — | — | CN | disclosed |