Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 5/20 | 0.50 |
| ▸ | EGFR | P00533 | 12/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28613599 | 1.00 | EPAS1 (0.50) | EPAS1EGFRAURKARPS6KB1LMNA | |
| SCHEMBL28614372 | 0.77 | EPAS1 (0.54) | EPAS1EGFRLMNA | |
| SCHEMBL29871021 | 0.77 | EPAS1 (0.54) | EPAS1EGFRLMNA | |
| SCHEMBL16095196 | 0.72 | EPAS1 (0.51) | EPAS1LMNASMN1; SMN2 | |
| SCHEMBL30002485 | 0.72 | EPAS1 (0.51) | EPAS1LMNASMN1; SMN2 | |
| SCHEMBL16095195 | 0.72 | EPAS1 (0.51) | EPAS1LMNASMN1; SMN2 | |
| SCHEMBL5372372 | 0.69 | EPAS1 (0.48) | EPAS1LMNA | |
| SCHEMBL13202776 | 0.69 | EPAS1 (0.59) | EPAS1SMN1; SMN2 | |
| SCHEMBL19667984 | 0.68 | EPAS1 (0.59) | EPAS1SMN1; SMN2 | |
| SCHEMBL20095129 | 0.68 | MAPKAPK2 (0.54) | EGFRRPS6KB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113292510-B | Benzisothiazole compound for inhibiting hypoxia inducible factor 2 activity, preparation method and application thereof | 中国药科大学 | 2022-08-26 | — | — | CN | disclosed |
| CN-113292510-A | Benzisothiazole compound for inhibiting hypoxia inducible factor 2 activity, preparation method and application thereof | 中国药科大学 | 2021-08-24 | — | — | CN | disclosed |