Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 3/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2853920 | 0.96 | MAPT (0.44) | MAPTKMT2AALDH1A1NPC1HPGD | |
| SCHEMBL2853923 | 0.96 | MAPT (0.44) | MAPTKMT2AALDH1A1NPC1HPGD | |
| SCHEMBL2856071 | 0.86 | CHRNA7 (0.44) | KMT2AALDH1A1HTR3ACHRNA7HTR3E | |
| SCHEMBL2856069 | 0.86 | CHRNA7 (0.44) | KMT2AALDH1A1HTR3ACHRNA7HTR3E | |
| SCHEMBL5386775 | 0.79 | HTR3A (0.42) | KMT2AALDH1A1NPC1HPGDNFKB1 | |
| SCHEMBL5267035 | 0.79 | HTR3A (0.42) | KMT2AALDH1A1NPC1HPGDNFKB1 | |
| SCHEMBL1965481 | 0.79 | HTR3A (0.50) | MAPTHTR3ACHRNA7 | |
| SCHEMBL1966763 | 0.79 | HTR3A (0.50) | MAPTHTR3ACHRNA7 | |
| SCHEMBL492684 | 0.74 | LSS (0.46) | CHRNA7CHRM1CHRM2CHRM3 | |
| SCHEMBL1572771 | 0.73 | MAPT (0.48) | MAPTKMT2AALDH1A1NPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828179-B1 | NICOTINIC ALPHA-7 RECEPTOR LIGANDS AGAINST CNS-RELATED DISEASES | MEMORY PHARM CORP (US) | 2010-01-20 | — | — | EP | claimed |