Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5267035 | 1.00 | HTR3A (0.42) | HTR3AGLAKMT2AMEN1TSHR | |
| SCHEMBL5265205 | 0.90 | GLA (0.45) | HTR3AGLAKMT2AMEN1TSHR | |
| SCHEMBL2853920 | 0.82 | MAPT (0.44) | HTR3AGLAKMT2AMEN1TSHR | |
| SCHEMBL2853923 | 0.82 | MAPT (0.44) | HTR3AGLAKMT2AMEN1TSHR | |
| SCHEMBL1963138 | 0.82 | HTR3A (0.50) | HTR3AALDH1A1HTR3EHTR3BCHRNA7 | |
| SCHEMBL5403686 | 0.82 | HTR3A (0.50) | HTR3AALDH1A1HTR3EHTR3BCHRNA7 | |
| Formic Acid SCHEMBL2861446 | 0.79 | MAPT (0.42) | HTR3AGLAKMT2AMEN1TSHR | |
| SCHEMBL5611010 | 0.74 | KDM4E (0.50) | KMT2AMEN1TSHRALDH1A1NPC1 | |
| SCHEMBL2856071 | 0.73 | CHRNA7 (0.44) | HTR3AGLAKMT2AMEN1TSHR | |
| SCHEMBL5402227 | 0.71 | CHRNA7 (0.45) | HTR3AALDH1A1HTR3EHTR3BCHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828179-A2 | NICOTINIC ALPHA-7 RECEPTOR LIGANDS AND PREPARATION AND USES THEREOF | Memory Pharmaceutical Corporation (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006069097-A2 | NICOTINIC ALPHA-7 RECEPTOR LIGANDS AND PREPARATION AND USES THEREOF | MEMORY PHARMACEUTICALS CORPORATION (US) | 2006-06-29 | — | — | WO | disclosed |