Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1552966 | 0.78 | KMT2A (0.49) | MAPTL3MBTL1MAPK1CYP2D6CYP2C19 | |
| SCHEMBL7324184 | 0.75 | SMN1; SMN2 (0.46) | MAPTL3MBTL1MAPK1SMN1; SMN2NPC1 | |
| SCHEMBL7324191 | 0.72 | SMN1; SMN2 (0.43) | MAPTL3MBTL1MAPK1SMN1; SMN2NPC1 | |
| SCHEMBL7833774 | 0.71 | HSD17B10 (0.48) | L3MBTL1MAPK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL28196510 | 0.71 | HSD17B10 (0.42) | MAPTNPC1RAB9AALDH1A1TSHR | |
| SCHEMBL2676616 | 0.70 | HPGD (0.47) | MAPTL3MBTL1MAPK1SMN1; SMN2NPC1 | |
| SCHEMBL27758107 | 0.70 | MAPT (0.42) | MAPTMAPK1SMN1; SMN2CYP3A4ALDH1A1 | |
| SCHEMBL29962795 | 0.69 | HPGD (0.62) | MAPTL3MBTL1MAPK1SMN1; SMN2NPC1 | |
| SCHEMBL78743 | 0.69 | HPGD (0.62) | MAPTL3MBTL1MAPK1SMN1; SMN2NPC1 | |
| SCHEMBL27873887 | 0.69 | HPGD (0.62) | MAPTL3MBTL1MAPK1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113329996-A | Compounds and methods for treating hedgehog pathway related disorders | 苏州麦迪耐斯医药科技有限公司 | 2021-08-31 | — | — | CN | disclosed |