Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30936706 | 0.80 | MAPT (0.59) | KMT2AMEN1ALDH1A1CRHBPCRHR2 | |
| SCHEMBL28614673 | 0.78 | MAPT (0.50) | KMT2AMEN1ALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL7833774 | 0.76 | HSD17B10 (0.48) | KMT2AMEN1ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL28096884 | 0.76 | CYP1A2 (0.46) | KMT2AMEN1ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL28196510 | 0.75 | HSD17B10 (0.42) | KMT2AMEN1ALDH1A1TDP1LMNA | |
| SCHEMBL7741213 | 0.75 | KMT2A (0.45) | KMT2AMEN1ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL27758107 | 0.74 | MAPT (0.42) | KMT2AMEN1ALDH1A1TDP1MAPK1 | |
| SCHEMBL27943657 | 0.74 | ALDH1A1 (0.44) | KMT2AMEN1ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL3960771 | 0.73 | KMT2A (0.53) | KMT2AMEN1ALDH1A1TDP1AR | |
| SCHEMBL13729336 | 0.73 | KDM4E (0.48) | KMT2AMEN1ALDH1A1L3MBTL1CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951724-B1 | FUSED BICYCLIC mTOR INHIBITORS | OSI PHARM INC (US) | 2011-04-27 | — | — | EP | disclosed |