Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 17/20 | 0.52 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL286065 | 0.88 | GABRA5 (0.65) | GABRA5ENPP2THRB | |
| SCHEMBL286329 | 0.86 | GABRA5 (0.55) | GABRA5ENPP2THRB | |
| SCHEMBL286317 | 0.85 | GABRA5 (0.66) | GABRA5ENPP2 | |
| SCHEMBL286659 | 0.84 | GABRA5 (0.52) | GABRA5 | |
| SCHEMBL286045 | 0.84 | GABRA5 (0.52) | GABRA5 | |
| SCHEMBL286425 | 0.84 | GABRA5 (0.52) | GABRA5 | |
| SCHEMBL286315 | 0.84 | GABRA5 (0.56) | GABRA5ENPP2THRB | |
| SCHEMBL286088 | 0.83 | GABRA5 (0.54) | GABRA5ENPP2KMT2ATHRB | |
| SCHEMBL286318 | 0.81 | GABRA5 (0.52) | GABRA5ENPP2THRB | |
| SCHEMBL286152 | 0.81 | GABRA5 (0.56) | GABRA5ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427455-A1 | ISOXAZOLE-PYRAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |