Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 16/20 | 0.54 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL286172 | 0.87 | GABRA5 (0.66) | GABRA5ENPP2THRB | |
| SCHEMBL286195 | 0.86 | GABRA5 (0.56) | GABRA5ENPP2KDM4ETHRB | |
| SCHEMBL285983 | 0.84 | GABRA5 (0.68) | GABRA5ENPP2KDM4E | |
| SCHEMBL286204 | 0.83 | GABRA5 (0.57) | GABRA5ENPP2KDM4ETHRB | |
| SCHEMBL286153 | 0.83 | GABRA5 (0.52) | GABRA5ENPP2THRBKMT2A | |
| SCHEMBL286087 | 0.80 | GABRA5 (0.57) | GABRA5ENPP2KDM4E | |
| SCHEMBL286566 | 0.80 | GABRA5 (0.53) | GABRA5ENPP2KDM4ETHRB | |
| SCHEMBL286432 | 0.80 | GABRA5 (0.54) | GABRA5ENPP2KDM4ETHRB | |
| SCHEMBL286286 | 0.79 | KDM4E (0.39) | GABRA5KDM4EKMT2A | |
| SCHEMBL286395 | 0.77 | GABRA5 (0.58) | GABRA5ENPP2KDM4ETHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427455-A1 | ISOXAZOLE-PYRAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |