Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL285884 | 0.88 | GABRA5 (0.54) | LMNAGABRA5GLAALDH1A1KDM4E | |
| SCHEMBL286497 | 0.88 | GABRA5 (0.46) | LMNAGABRA5GLAALDH1A1KDM4E | |
| SCHEMBL285946 | 0.86 | GABRA5 (0.47) | LMNAGABRA5GLAALDH1A1KDM4E | |
| SCHEMBL285782 | 0.85 | GABRA5 (0.47) | LMNAGABRA5GLAALDH1A1KDM4E | |
| SCHEMBL285667 | 0.85 | KDM4E (0.53) | LMNAGABRA5GLAALDH1A1KDM4E | |
| SCHEMBL286079 | 0.82 | KDM4E (0.56) | LMNAGABRA5ALDH1A1KDM4EITGA5 | |
| SCHEMBL286169 | 0.82 | GABRA5 (0.56) | LMNAGABRA5KDM4EITGA5GAA | |
| SCHEMBL18091996 | 0.81 | GABRA5 (0.46) | LMNAGABRA5GLAALDH1A1KDM4E | |
| SCHEMBL286063 | 0.81 | KDM4E (0.44) | LMNAGABRA5KDM4EITGA5KMT2A | |
| SCHEMBL285707 | 0.79 | GABRA5 (0.43) | GABRA5KDM4EITGA5GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427459-A1 | ISOXAZOLE-THIAZOLE DERIVATIVES AS GABA A RECEPTOR INVERSE AGONISTS FOR USE IN THE TREATMENT OF COGNITIVE DISORDERS | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |