Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 15/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL285655 | 0.88 | GABRA5 (0.56) | GABRA5ALDH1A1LMNA | |
| SCHEMBL286159 | 0.86 | LMNA (0.47) | GABRA5ALDH1A1KDM4ELMNAGLA | |
| SCHEMBL286176 | 0.86 | GABRA5 (0.49) | GABRA5 | |
| SCHEMBL286230 | 0.85 | GABRA5 (0.53) | GABRA5ALDH1A1KDM4EGLA | |
| SCHEMBL286205 | 0.83 | GABRA5 (0.47) | GABRA5ALDH1A1KDM4E | |
| SCHEMBL285762 | 0.82 | GABRA5 (0.50) | GABRA5 | |
| SCHEMBL285848 | 0.81 | GABRA5 (0.56) | GABRA5KDM4E | |
| SCHEMBL285752 | 0.80 | GABRA5 (0.58) | GABRA5KDM4E | |
| SCHEMBL285763 | 0.80 | GABRA5 (0.49) | GABRA5KDM4E | |
| SCHEMBL285944 | 0.79 | GABRA5 (0.59) | GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427459-A1 | ISOXAZOLE-THIAZOLE DERIVATIVES AS GABA A RECEPTOR INVERSE AGONISTS FOR USE IN THE TREATMENT OF COGNITIVE DISORDERS | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |