Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 8/20 | 0.60 |
| ▸ | APP | P05067 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29870974 | 1.00 | EPAS1 (0.60) | EPAS1APPMAPTAURKARPS6KB1 | |
| SCHEMBL13202702 | 0.86 | EPAS1 (0.52) | EPAS1APPMAPTACHE | |
| SCHEMBL29870643 | 0.83 | AURKA (0.46) | EPAS1MAPTAURKARPS6KB1ACHE | |
| SCHEMBL29870793 | 0.83 | ACHE (0.44) | EPAS1APPMAPTACHELMNA | |
| SCHEMBL29871039 | 0.83 | APP (0.54) | EPAS1APPACHEMAPK1HTT | |
| SCHEMBL28616350 | 0.83 | APP (0.54) | EPAS1APPACHEMAPK1HTT | |
| SCHEMBL29870666 | 0.83 | CCNE2 (0.55) | EPAS1APPMAPTAURKARPS6KB1 | |
| SCHEMBL28613603 | 0.83 | ACHE (0.44) | EPAS1APPMAPTACHELMNA | |
| SCHEMBL28629152 | 0.83 | AURKA (0.46) | EPAS1MAPTAURKARPS6KB1ACHE | |
| SCHEMBL28623278 | 0.83 | ACHE (0.44) | EPAS1MAPTEGFRACHELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113292510-B | Benzisothiazole compound for inhibiting hypoxia inducible factor 2 activity, preparation method and application thereof | 中国药科大学 | 2022-08-26 | — | — | CN | disclosed |
| CN-113292510-A | Benzisothiazole compound for inhibiting hypoxia inducible factor 2 activity, preparation method and application thereof | 中国药科大学 | 2021-08-24 | — | — | CN | disclosed |