Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 6/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | SLC2A4 | P14672 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29870643 | 1.00 | AURKA (0.46) | AURKARPS6KB1AURKBACHEEPAS1 | |
| SCHEMBL28623278 | 0.86 | ACHE (0.44) | ACHEEPAS1MAPTLMNATP53 | |
| SCHEMBL29870797 | 0.86 | ACHE (0.44) | ACHEEPAS1MAPTLMNATP53 | |
| SCHEMBL29870666 | 0.83 | CCNE2 (0.55) | AURKARPS6KB1AURKBACHEEPAS1 | |
| SCHEMBL29871039 | 0.83 | APP (0.54) | ACHEEPAS1MAPK1KMT2A | |
| SCHEMBL28616319 | 0.83 | EPAS1 (0.60) | AURKARPS6KB1ACHEEPAS1ALOX15 | |
| SCHEMBL29870974 | 0.83 | EPAS1 (0.60) | AURKARPS6KB1ACHEEPAS1ALOX15 | |
| SCHEMBL28616350 | 0.83 | APP (0.54) | ACHEEPAS1MAPK1KMT2A | |
| SCHEMBL28613603 | 0.83 | ACHE (0.44) | ACHEEPAS1MAPTLMNAKDM4E | |
| SCHEMBL29870793 | 0.83 | ACHE (0.44) | ACHEEPAS1MAPTLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113292510-B | Benzisothiazole compound for inhibiting hypoxia inducible factor 2 activity, preparation method and application thereof | 中国药科大学 | 2022-08-26 | — | — | CN | disclosed |
| CN-113292510-A | Benzisothiazole compound for inhibiting hypoxia inducible factor 2 activity, preparation method and application thereof | 中国药科大学 | 2021-08-24 | — | — | CN | disclosed |