Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 14/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28617199 | 1.00 | STING1 (0.49) | STING1CSF1RSMPD1HDAC1HDAC8 | |
| Bromide SCHEMBL19436508 | 1.00 | STING1 (0.49) | STING1CSF1RSMPD1HDAC1HDAC8 | |
| SCHEMBL26764205 | 0.91 | CSF1R (0.47) | STING1CSF1R | |
| SCHEMBL22121334 | 0.87 | STING1 (0.50) | STING1 | |
| SCHEMBL28919114 | 0.84 | STING1 (0.47) | STING1 | |
| SCHEMBL19436570 | 0.84 | STING1 (0.47) | STING1 | |
| SCHEMBL22121390 | 0.83 | STING1 (0.57) | STING1 | |
| SCHEMBL29868209 | 0.83 | STING1 (0.49) | STING1 | |
| SCHEMBL29868591 | 0.83 | STING1 (0.49) | STING1 | |
| SCHEMBL22121384 | 0.82 | STING1 (0.63) | STING1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109608443-B | Heterocyclic amides as protein modulators | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-09-07 | — | — | CN | disclosed |
| CN-109071514-B | Heterocyclic amides as protein modulators | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-07-06 | — | — | CN | disclosed |