SCHEMBL26764205

SCHEMBL26764205

COc1ccc(COc2cc(C(N)=O)cc3nc(N)n(C/C=C/Cn4c(N)nc5cc(C(N)=O)cc(OC)c54)c23)cc1

nearest known ligand 0.47

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ CSF1R P07333 6/20 0.47
▸ STING1 Q86WV6 11/20 0.46
▸ NTRK1 P04629 4/20 0.43
▸ NTRK2 Q16620 4/20 0.43
▸ PLK1 P53350 1/20 0.42
▸ ENPP1 P22413 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL28617199 0.91 STING1 (0.49) CSF1RSTING1
Bromide SCHEMBL28617201 0.91 STING1 (0.49) CSF1RSTING1
Bromide SCHEMBL19436508 0.91 STING1 (0.49) CSF1RSTING1
SCHEMBL22121334 0.87 STING1 (0.50) STING1
SCHEMBL22121390 0.83 STING1 (0.57) STING1
SCHEMBL29868591 0.83 STING1 (0.49) STING1
SCHEMBL29868209 0.83 STING1 (0.49) STING1
SCHEMBL22121384 0.82 STING1 (0.63) STING1
SCHEMBL28941702 0.82 STING1 (0.63) STING1
SCHEMBL19436570 0.82 STING1 (0.47) STING1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023215740-A1 IMMUNOMODULATORY ANTIBODY-DRUG CONJUGATES SEAGEN INC. (US) 2023-11-09 — — WO disclosed
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