Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | CETP | P11597 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31381754 | 1.00 | TP53 (0.50) | TP53HPGDKMT2APLAUNPC1 | |
| SCHEMBL28669892 | 0.83 | NPC1 (0.63) | TP53HPGDKMT2ANPC1GAA | |
| SCHEMBL123452 | 0.81 | LMNA (0.51) | TP53HPGDPLAUNPC1GAA | |
| SCHEMBL3415512 | 0.78 | KMT2A (0.49) | TP53KMT2ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL27839469 | 0.77 | PLAU (0.47) | HPGDKMT2APLAUNPC1GAA | |
| SCHEMBL5699255 | 0.77 | GAA (0.44) | HPGDPLAUNPC1GAAPKM | |
| SCHEMBL20560218 | 0.76 | HTT (0.46) | TP53HPGDKMT2ANPC1GAA | |
| SCHEMBL146375 | 0.76 | RXFP1 (0.50) | HPGDKMT2ANPC1GAAHDAC1 | |
| SCHEMBL4744831 | 0.76 | SMN1; SMN2 (0.67) | KMT2ANPC1GAAPKMCETP | |
| SCHEMBL18554486 | 0.76 | CTSC (0.42) | TP53KMT2ASMN1; SMN2MEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113015526-A | Spirocyclic 2, 3-dihydro-7-azaindole compounds and uses thereof | 豪夫迈·罗氏有限公司 | 2021-06-22 | — | — | CN | disclosed |