Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.77 |
| ▸ | EGFR | P00533 | 3/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.77 |
| ▸ | PKM | P14618 | 1/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 9/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.64 |
| ▸ | TSHR | P16473 | 7/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.64 |
| ▸ | USP2 | O75604 | 5/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | GLA | P06280 | 1/20 | 0.64 |
| ▸ | PDE5A | O76074 | 3/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28611828 | 0.90 | MEN1 (0.73) | MAPTEGFRNPSR1PKMCYP1A2 | |
| SCHEMBL1083926 | 0.87 | MAPT (1.00) | MAPTEGFRNPSR1PKMCYP1A2 | |
| SCHEMBL29754288 | 0.87 | MAPT (1.00) | MAPTEGFRNPSR1PKMCYP1A2 | |
| SCHEMBL28604939 | 0.85 | CYP1A2 (0.78) | MAPTEGFRNPSR1PKMCYP1A2 | |
| SCHEMBL28606239 | 0.85 | EGFR (0.76) | MAPTEGFRNPSR1PKMCYP1A2 | |
| SCHEMBL28604946 | 0.84 | EGFR (0.72) | MAPTEGFRNPSR1PKMALDH1A1 | |
| SCHEMBL1064854 | 0.79 | CYP1A2 (1.00) | MAPTEGFRNPSR1PKMCYP1A2 | |
| SCHEMBL7277274 | 0.78 | CYP1A2 (1.00) | MAPTNPSR1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7285873 | 0.76 | PDE5A (0.78) | MAPTCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL1084041 | 0.76 | KMT2A (1.00) | MAPTEGFRNPSR1PKMCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113248448-A | 2-arylamine-4-amino quinazoline compound, preparation method and application thereof | 江苏正大丰海制药有限公司 | 2021-08-13 | — | — | CN | claimed |
| CN-113248448-A | 2-arylamine-4-amino quinazoline compound, preparation method and application thereof | 江苏正大丰海制药有限公司 | 2021-08-13 | — | — | CN | disclosed |