Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.61 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | APLNR | P35414 | 1/20 | 0.56 |
| ▸ | GLP1R | P43220 | 1/20 | 0.56 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.56 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2865254 | 0.89 | NPSR1 (0.64) | NPSR1ADRB2APLNRGLP1RFFAR4 | |
| SCHEMBL6039445 | 0.85 | NPSR1 (0.64) | NPSR1ADRB2APLNRGLP1RFFAR4 | |
| SCHEMBL2866700 | 0.85 | NPSR1 (0.56) | NPSR1ADRB2APLNRGLP1RFFAR4 | |
| SCHEMBL2861556 | 0.85 | NPSR1 (0.61) | NPSR1ADRB2APLNRGLP1RFFAR4 | |
| Hydrochloric Acid SCHEMBL2862015 | 0.84 | NPSR1 (0.63) | NPSR1ADRB2APLNRGLP1RFFAR4 | |
| SCHEMBL2868953 | 0.83 | NPSR1 (0.57) | NPSR1ADRB2APLNRGLP1RFFAR4 | |
| SCHEMBL2860846 | 0.80 | NPSR1 (0.65) | NPSR1ADRB2APLNRGLP1RFFAR4 | |
| SCHEMBL2861708 | 0.79 | NPSR1 (0.72) | NPSR1ADRB2APLNRGLP1RFFAR4 | |
| SCHEMBL2870919 | 0.78 | NPSR1 (0.63) | NPSR1ADRB2APLNRGLP1RFFAR4 | |
| SCHEMBL2867186 | 0.78 | NPSR1 (0.71) | NPSR1ADRB2APLNRGLP1RFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795267-B2 | Bicyclic piperazine compound having TGR23 antagonistic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-14 | — | — | US | disclosed |
| US-20070072865-A1 | Bicyclic piperazine compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-03-29 | — | — | US | disclosed |
| EP-1661898-A1 | BICYCLIC PIPERAZINE COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2006-05-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072865-A1 | Bicyclic piperazine compound and use thereof | GPR3, FFAR3, LPAR3 | NPSR1 211/4885ADRB2 449/4885APLNR 136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.