Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ESRRB | O95718 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESRRA | P11474 | 1/20 | 0.40 |
| ▸ | ESRRG | P62508 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28624185 | 0.89 | DRD2 (0.46) | DRD2DRD4ARAKR1C3SLC6A2 | |
| SCHEMBL28885189 | 0.77 | KMT2A (0.33) | MAPT | |
| SCHEMBL4465716 | 0.76 | CYP2D6 (0.34) | ALDH1A1LMNA | |
| SCHEMBL5015647 | 0.76 | AKR1C3 (0.65) | AKR1C3MAPTALDH1A1NPSR1GAA | |
| SCHEMBL4475027 | 0.75 | HSD17B10 (0.39) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL28965497 | 0.71 | PPARG (0.37) | DRD2MAPTALDH1A1DRD3LMNA | |
| SCHEMBL24511303 | 0.70 | DRD2 (0.48) | DRD2DRD4ARAKR1C3SLC6A2 | |
| SCHEMBL22805291 | 0.70 | AKR1C3 (0.58) | AKR1C3MAPTALDH1A1NPSR1GAA | |
| SCHEMBL21877150 | 0.70 | GPR119 (0.56) | DRD2DRD4MAPTALDH1A1ESRRB | |
| SCHEMBL26101572 | 0.69 | AKR1C3 (0.39) | DRD2DRD4AKR1C3SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113164775-A | Polycyclic compounds and methods for rapid accelerated targeted degradation of fibrosarcoma polypeptides | 阿尔维纳斯运营股份有限公司 | 2021-07-23 | — | — | CN | disclosed |