Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2863284 | 0.82 | POLB (0.51) | POLBALDH1A1TSHRSMN1; SMN2HTT | |
| SCHEMBL13225045 | 0.80 | POLB (0.51) | POLBALDH1A1TSHRSMN1; SMN2HTT | |
| SCHEMBL2863267 | 0.80 | JAK2 (0.37) | HTTKMT2AMEN1 | |
| SCHEMBL2862230 | 0.76 | MKNK2 (0.32) | POLB | |
| SCHEMBL3501245 | 0.72 | POLB (0.52) | POLBALDH1A1TSHRSMN1; SMN2HTT | |
| SCHEMBL2858246 | 0.70 | MAPT (0.43) | SMN1; SMN2 | |
| SCHEMBL2870379 | 0.69 | LYN (0.34) | — | |
| SCHEMBL3501861 | 0.66 | POLB (0.81) | POLBALDH1A1TSHRSMN1; SMN2HTT | |
| SCHEMBL4730919 | 0.65 | POLB (0.58) | POLBALDH1A1TSHRSMN1; SMN2HTT | |
| SCHEMBL2865380 | 0.65 | JAK2 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200612-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-06-30 | — | — | EP | claimed |
| WO-2009035575-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2009-03-19 | — | — | WO | claimed |
| EP-2200612-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009035575-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2009-03-19 | — | — | WO | disclosed |