Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734755 | 0.91 | POLB (0.46) | POLBTSHRALDH1A1SMN1; SMN2HTT | |
| SCHEMBL4732610 | 0.89 | NR2F2 (0.51) | POLBALDH1A1SMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL4781177 | 0.88 | KMT2A (0.49) | POLBALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL4734768 | 0.82 | MEN1 (0.57) | POLBALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL4733867 | 0.81 | MEN1 (0.46) | POLBTSHRALDH1A1SMN1; SMN2HTT | |
| SCHEMBL4731333 | 0.77 | PRMT5 (0.46) | ALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL4734747 | 0.76 | KMT2A (0.48) | POLBALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL4732276 | 0.76 | CNR2 (0.41) | KMT2AMEN1 | |
| SCHEMBL4732203 | 0.75 | CYP19A1 (0.59) | ALDH1A1KMT2A | |
| SCHEMBL4733368 | 0.74 | CHRM2 (0.41) | KMT2AMEN1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |