Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL31758441 | 1.00 | HPGD (0.45) | HPGDKMT2AALDH1A1MAPTKDM4E | |
| Bicarbonate SCHEMBL15652769 | 0.94 | HPGD (0.46) | HPGDKMT2AALDH1A1MAPTKDM4E | |
| Carbamic Acid SCHEMBL8982281 | 0.90 | HPGD (0.44) | HPGDKMT2AALDH1A1MAPTKDM4E | |
| Methyl Alcohol SCHEMBL9328801 | 0.90 | ALDH1A1 (0.48) | HPGDKMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL22522 | 0.89 | ALDH1A1 (0.52) | HPGDKMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL7102666 | 0.89 | ALDH1A1 (0.52) | HPGDKMT2AALDH1A1MAPTKDM4E | |
| Carbamic Acid SCHEMBL11339972 | 0.89 | HPGD (0.43) | HPGDKMT2AALDH1A1MAPTKDM4E | |
| Hydroxyamine SCHEMBL8674115 | 0.88 | ALDH1A1 (0.47) | HPGDKMT2AALDH1A1MAPTKDM4E | |
| Ammonia Solution, Strong SCHEMBL10613596 | 0.87 | ALDH1A1 (0.50) | HPGDKMT2AALDH1A1MAPTKDM4E | |
| Ammonia Solution, Strong SCHEMBL7735826 | 0.87 | ALDH1A1 (0.50) | HPGDKMT2AALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122042984-A | Kit for screening people with high risk of liver injury caused by chemotherapeutic drug methotrexate and application of detection reagent in preparation of methotrexate liver injury prediction product | 中南大学湘雅二医院 | 2026-05-15 | — | — | CN | disclosed |
| CN-113795246-B | Injectable sustained release formulation for the treatment of joint pain and inflammation | 福多兹制药公司 | 2024-10-11 | — | — | CN | disclosed |
| CN-117980487-A | Methods and compositions for non-viral DNA delivery | 斯帕克治疗公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-116964207-A | Methods for enhancing nonviral gene therapy | 斯帕克治疗公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-113164589-A | Compositions and methods for modulating monocyte and macrophage inflammatory phenotype and immunotherapy uses thereof | 维西欧制药公司 | 2021-07-23 | — | — | CN | disclosed |