Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ELANE | P08246 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | FABP7 | O15540 | 2/20 | 0.42 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | FABP3 | P05413 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13292719 | 1.00 | POLB (0.58) | POLBL3MBTL1KMT2ASMN1; SMN2HTT | |
| SCHEMBL15092194 | 0.81 | POLB (0.84) | POLBL3MBTL1KMT2ASMN1; SMN2HTT | |
| SCHEMBL4120652 | 0.79 | POLB (0.58) | POLBL3MBTL1KMT2ASMN1; SMN2HTT | |
| SCHEMBL27779967 | 0.79 | POLB (0.58) | POLBL3MBTL1KMT2ASMN1; SMN2HTT | |
| SCHEMBL27947134 | 0.79 | LMNA (0.61) | POLBL3MBTL1KMT2ASMN1; SMN2HTT | |
| SCHEMBL23291730 | 0.79 | POLB (0.58) | POLBL3MBTL1KMT2ASMN1; SMN2HTT | |
| SCHEMBL17287375 | 0.79 | POLB (0.58) | POLBL3MBTL1KMT2ASMN1; SMN2HTT | |
| SCHEMBL4544899 | 0.79 | LMNA (0.61) | POLBL3MBTL1KMT2ASMN1; SMN2HTT | |
| SCHEMBL6689211 | 0.79 | POLB (0.58) | POLBL3MBTL1KMT2ASMN1; SMN2HTT | |
| SCHEMBL13292722 | 0.78 | KMT2A (0.68) | POLBL3MBTL1KMT2ASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113348167-A | (pyridin-2-yl) amine derivatives as TGF-beta R1(ALK5) inhibitors for the treatment of cancer | 奈可萨斯医药有限公司 | 2021-09-03 | — | — | CN | disclosed |