Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | ALPL | P05186 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | QPCT | Q16769 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21807641 | 0.86 | NPC1 (0.69) | NPC1RAB9AHTTMEN1KMT2A | |
| SCHEMBL1276739 | 0.77 | KMT2A (0.79) | NPC1RAB9AL3MBTL1HTTMEN1 | |
| SCHEMBL23794884 | 0.76 | NPC1 (0.54) | NPC1RAB9AHTTLMNAALDH1A1 | |
| SCHEMBL2396667 | 0.73 | SMN1; SMN2 (0.53) | NPC1RAB9AHTTLMNAALDH1A1 | |
| SCHEMBL9371077 | 0.73 | SMN1; SMN2 (0.53) | NPC1RAB9AHTTLMNAALDH1A1 | |
| SCHEMBL6496157 | 0.72 | MAPT (0.56) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL24221991 | 0.71 | NPC1 (0.69) | NPC1RAB9AHTTMEN1CYP1A2 | |
| SCHEMBL18421576 | 0.71 | NPC1 (0.65) | NPC1RAB9AL3MBTL1HTTLMNA | |
| SCHEMBL5451731 | 0.70 | ALDH1A1 (0.74) | NPC1RAB9AHTTMEN1CYP1A2 | |
| SCHEMBL1310574 | 0.70 | GAA (0.78) | NPC1RAB9AL3MBTL1HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112566910-A | Thiophene derivatives for the treatment of IgE induced diseases | UCB生物制药有限责任公司 | 2021-03-26 | — | — | CN | disclosed |