Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 10/20 | 0.45 |
| ▸ | P2RX2 | Q9UBL9 | 7/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2866604 | 0.89 | P2RX3 (0.55) | P2RX3P2RX2MCHR1CNR1CNR2 | |
| SCHEMBL2868273 | 0.81 | HTR2C (0.48) | — | |
| SCHEMBL4339725 | 0.80 | TTBK1 (0.51) | CNR1CNR2 | |
| SCHEMBL2847817 | 0.79 | APP (0.41) | — | |
| SCHEMBL2867255 | 0.75 | P2RX3 (0.55) | P2RX3P2RX2 | |
| SCHEMBL4759238 | 0.74 | P2RX3 (0.58) | P2RX3P2RX2 | |
| SCHEMBL2857789 | 0.74 | P2RX3 (0.36) | P2RX3P2RX2GRIN2BMCHR1 | |
| SCHEMBL2862214 | 0.74 | P2RX3 (0.58) | P2RX3P2RX2 | |
| SCHEMBL4340134 | 0.73 | P2RX3 (0.65) | P2RX3P2RX2 | |
| SCHEMBL4341209 | 0.73 | P2RX3 (0.66) | P2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139334-A1 | 2-CYANOPHENYL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF | Renovis, Inc. (US) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008130481-A1 | 2-CYANOPHENYL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF | RENOVIS, INC. (US) | 2008-10-30 | — | — | WO | disclosed |