Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 9/20 | 0.55 |
| ▸ | P2RX2 | Q9UBL9 | 7/20 | 0.55 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 2/20 | 0.46 |
| ▸ | MYLK | Q15746 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | CLPP | Q16740 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 6/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2863092 | 0.91 | P2RX3 (0.66) | P2RX3P2RX2FAAHCLPP | |
| SCHEMBL2849779 | 0.84 | FAAH (0.70) | P2RX3P2RX2FAAH | |
| SCHEMBL4340084 | 0.83 | CLPP (0.50) | AKT1MYLKMAPK14CLPPMEN1 | |
| SCHEMBL4759871 | 0.80 | P2RX3 (0.64) | P2RX3P2RX2FAAH | |
| SCHEMBL2867254 | 0.80 | P2RX3 (0.64) | P2RX3P2RX2FAAH | |
| SCHEMBL4340134 | 0.79 | P2RX3 (0.65) | P2RX3P2RX2 | |
| SCHEMBL4341209 | 0.78 | P2RX3 (0.66) | P2RX3P2RX2 | |
| SCHEMBL2860308 | 0.77 | P2RX3 (0.57) | P2RX3P2RX2CLPP | |
| SCHEMBL16510168 | 0.77 | BRS3 (0.49) | P2RX3P2RX2CLPPMEN1KMT2A | |
| SCHEMBL4872158 | 0.76 | FAAH (0.73) | P2RX3P2RX2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139334-A1 | 2-CYANOPHENYL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF | Renovis, Inc. (US) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008130481-A1 | 2-CYANOPHENYL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF | RENOVIS, INC. (US) | 2008-10-30 | — | — | WO | disclosed |