Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.65 |
| ▸ | PRKCG | P05129 | 2/20 | 0.65 |
| ▸ | PRKCB | P05771 | 2/20 | 0.65 |
| ▸ | PRKCA | P17252 | 2/20 | 0.65 |
| ▸ | PRKCH | P24723 | 2/20 | 0.65 |
| ▸ | PRKCI | P41743 | 2/20 | 0.65 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.65 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.65 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.65 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.65 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.65 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | AKT1 | P31749 | 2/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | CDC25A | P30304 | 1/20 | 0.52 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL25306967 | 1.00 | PRKD3 (0.65) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Hydrochloric Acid SCHEMBL116535 | 1.00 | PRKD3 (0.65) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Hydrochloric Acid SCHEMBL597002 | 1.00 | PRKD3 (0.65) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Water SCHEMBL29707870 | 0.98 | PRKD3 (0.62) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Hydrochloric Acid SCHEMBL253903 | 0.98 | PRKD3 (0.61) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL5447359 | 0.98 | PRKD3 (0.67) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL8855786 | 0.98 | PRKD3 (0.67) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL8855744 | 0.98 | PRKD3 (0.67) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL8855768 | 0.98 | PRKD3 (0.67) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL8855806 | 0.98 | PRKD3 (0.67) | PRKD3PRKCGPRKCBPRKCAPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113358528-B | Method for detecting acetylcholinesterase and inhibitor thereof based on pendant drop method | 山东大学 | 2022-06-17 | — | — | CN | claimed |
| CN-113358528-A | Method for detecting acetylcholinesterase and inhibitor thereof based on pendant drop method | 山东大学 | 2021-09-07 | — | — | CN | claimed |
| CN-113358528-B | Method for detecting acetylcholinesterase and inhibitor thereof based on pendant drop method | 山东大学 | 2022-06-17 | — | — | CN | disclosed |
| CN-113358528-A | Method for detecting acetylcholinesterase and inhibitor thereof based on pendant drop method | 山东大学 | 2021-09-07 | — | — | CN | disclosed |