Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL10453278 | 0.94 | CYP1A2 (0.39) | ALOX5SLC1A3SLC1A2SLC1A1LMNA | |
| Bicarbonate SCHEMBL6470832 | 0.92 | CYP1A2 (0.42) | ALOX5FFAR3LMNACYP1A2CYP2D6 | |
| SCHEMBL5017989 | 0.90 | ALOX5 (0.35) | ALOX5SLC1A3SLC1A2SLC1A1POLB | |
| Acetone SCHEMBL254033 | 0.89 | ALOX5 (0.38) | ALOX5POLBLMNACYP1A2CYP19A1 | |
| Bicarbonate SCHEMBL10453065 | 0.88 | — | — | |
| Acetic Acid SCHEMBL27585871 | 0.86 | CYP1A2 (0.37) | ALOX5SLC1A3SLC1A2SLC1A1FFAR3 | |
| Methyl Alcohol SCHEMBL21227036 | 0.85 | — | — | |
| SCHEMBL5691759 | 0.85 | CYP1A2 (0.41) | POLBCYP1A2 | |
| SCHEMBL5684 | 0.85 | — | — | |
| Carbamic Acid SCHEMBL7781024 | 0.84 | ALOX5 (0.45) | ALOX5SLC1A3SLC1A2SLC1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8822366-B2 | Solid titanium catalyst component, catalyst for olefin polymerization and process for polymerizing olefin | MITSUI CHEMICALS, INC. (JP) | 2014-09-02 | — | — | US | disclosed |
| EP-2206731-B1 | SOLID TITANIUM CATALYST COMPONENT, OLEFIN POLYMERIZATION CATALYST, AND OLEFIN POLYMERIZATION METHOD | MITSUI CHEMICALS INC (JP) | 2013-08-28 | — | — | EP | disclosed |
| US-20100227991-A1 | SOLID TITANIUM CATALYST COMPONENT, CATALIST FOR OLEFIN POLYMERIZATION AND PROCESS FOR POLYMERIZING OLEFIN | MITSUI CHEMICALS, INC. (JP) | 2010-09-09 | — | — | US | disclosed |
| EP-2206731-A1 | SOLID TITANIUM CATALYST COMPONENT, OLEFIN POLYMERIZATION CATALYST, AND OLEFIN POLYMERIZATION METHOD | Mitsui Chemicals, Inc. (JP) | 2010-07-14 | — | — | EP | disclosed |